The relationship between bone health and plasma zinc, copper lead and cadmium concentration in osteoporotic women

Osteoporosis is a multi factorial disease with dimension of genetic and nutritional considerations. the aim of this studywas to present data from the association of plasma zinc, copper and toxic elements of lead and cadmium levels withbone mineral density in iranian women. 135 women gave their information and enrolled. fasting plasma was used formeasurement of trace elements and heavy metals by differential pulse anodic stripping voltammetry. control group(n = 51) were normal in both lumbar spine (l1-l4) and femoral neck density (t-score ? ?1), but just femoral neckt-score was considered as criterion in selection of patient group (n = 49, tscore < ?1). no differences were foundin the nutritional status, number of diseases, drugs and functional activities between these groups. plasma zn, cu,pb, cd levels were analyzed by, a method of voltammetry. mean ± sd levels of copper and zinc was 1.168 ± 0.115,1.097 ± 0.091 ?g/ml in control group, 1.394 ± 0.133, 1.266 ± 0.11 ?g/ml in total patient (tp) and 1.237 ± 0.182,1.127 ± 0.176 ?g/ml in mild patients(?1 > t-score > ?1.7), 1.463 ± 0.174, 1.327 ± 0.147 ?g/ml in severe patientgroup (t-score < ?1.7); respectively. mean ± sd plasma level of lead and cadmium was 168.42 ± 9.61 ng/l,2.91 ± 0.18 ng/ml in control group, 176.13 ± 8.64 ng/l, 2.97 ± 0.21 ng/ml in tp, 176.43 ± 13.2 ng/l, 2.99 ± 0.1 ng/ml inmild patients, 221.44 ± 20 ng/l and 3.80 ± 0.70 ng/ml in severe patient group, respectively. in this study plasmazinc, copper, lead & cadmium concentrations were higher in the patients than in the control, though differenceswere not significant. however, differences were higher between the controls and patients with severe disease(t-score < ?1.7). in addition adjusted t-score of femur with age and bmi showed negative significant correlationwith plasma levels of zinc and lead in total participants (p < 0.05, r = ?0.201, p = 0.044, r = ?0.201). it seems that moreextensive study with larger ample size might supply definite results about this association for copper and cadmium.