Association of urinary bisphenol a concentration with type-2 diabetes mellitus

Background: bisphenol a as an endocrine-disrupting chemical is widely used chemical in the manufacture ofpolycarbonate plastics and epoxy resin and has become ubiquitous environmental contaminants. human exposure tobisphenol a is widespread and recent studies have been shown to be associated with a higher risk for self-reportedadverse health outcomes that may lead to insulin resistance and the development of type-2 diabetes mellitus. in thiscontext, we sought to confirm the association between bisphenol a and diabetes in a community-based analysis ofbisphenol a urinary concentrations investigation in adult population of iran.me th ods : regression models were adjusted for age, sex, body mass index, serum triglyceride level and serumcholesterol level and serum creatinine concentration. main outcomes were reported diagnoses of diabetes thatdefined according the latest american diabetes association guidelines.r e s u l t s : the median age of the 239 participants was 51.65 years and 119 people had type-2 diabetes mellitus.urinary bisphenol a was categorized into two groups based on the median for bisphenol a (?0. 85 to > 0.85 ?g/l). theresults of statistical analysis revealed a clear association between hypertension, and type 2 diabetes (p < 0.05). the multivariable-adjusted odds ratio for type-2 diabetes mellitus associated with the group 1 (referent), of urinary bisphenol awas 57.6 (95% confidence interval: 21.10-157.05; p-value < 0.001). a positive correlation between hba1c and urinarybpa concentration was observed (r = 0.63, p = 0.001).conclusions: urinary bisphenol a levels are found to be associated with diabetes independent of traditional diabetesrisk factors. higher bisphenol a exposure, reflected in higher urinary concentrations of bisphenol a, is consistentlyassociated with diabetes in the general adult population of the iran. studies to clarify the mechanisms of theseassociations are urgently needed.