Synthesis and study the controlled release of etronidazole from the new PEG/NaY and PEG/MCM-41 nanocomposites

Recently, hybrid materials using poly ethylene glycol and porous nanocrystals have been developed for drugrelease. in this study, a series of poly ethylene glycol (peg)/nay zeolite and peg/mcm-41 nanocomposites getsynthesized. these materials are characterized using ft-ir spectroscopy, xrd, tga and sem. after loading themetronidazole onto these nanocomposites, the release of metronidazole was studied in two kinds of release fluidssimulating body fluid kh2po4-na2hpo4 buffer (ph = 7.4) and gastric fluid (hcl aqueous solution, ph = 1.5) whilecontrolling the time, ph values, and temperature using uv–vis. results showed that these nanocomposites havefurther release related to nay, mcm-41 and the order of release in two ph solutions was peg/nay > peg/mcm-41 > nay > mcm-41. the behavior of drug release in these nanocomposites is probably due to hydrogen bondinginteractions between drug and the hydroxyl group on the composite framework.