nano γ-al2o3: enhancement of catalytic performance in the synthesis of bis (indolyl) methanes

Abstract the synthesis of bis(indolyl)methane derivatives in the reaction between indoles and aldehydes was carried out in a short reaction time (10-20 minutes) with good yield (78-96%) by using 1 mol% of nanoγ-al2o3in h2o as a green solvent at room temperature. moreover, we usednanoγ-al2o3 as an effortlessly accessible, less costly, and possible under eco-friendly conditions catalyst in this method. consequently, this method presented significant benefits containing a low amount of the catalyst, purification of target molecules by non-chromatographic process, use of recyclability of the catalyst, simply efficient, green, and suitable for the synthesis of a broad range of bis(indolyl)methane derivatives. this method achieves to have a numerous scope concerning the difference in the aldehydes and indoles. moreover, water was the only by-product, which added to its attractiveness. bis(indolyl)methane derivatives have a varied range of bioactive metabolites of native and marine sources. the hydrothermal and chemical stability of γ-al2o3 is a severe point for catalytic applications. the melting point, ft-ir, and 1h nmr spectra of the selected product showed that these products were synthesized successfully.