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synthesis of cis-diammine (1,1-cyclobutane dicarboxylate) platinum(ii)
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نویسنده
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nemati kharat ali ,tamaddoni jahromi bahareh ,mohammadifar ehsan ,zareyi jaleh
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منبع
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iranian journal of chemistry and chemical engineering - 2017 - دوره : 36 - شماره : 4 - صفحه:39 -43
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چکیده
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Platinum-based anticancer drugs are chemotherapeutic agents to treat cancer. carboplatin (cis diammine cyclobutane dicarboxylate platinum (ii)) is a second generation drug that has less toxic than cisplatin, allowing for high dosages. in the first stage, 1,3-cyclobutane dicarboxylic acid, a key intermediate for preparation of carboplatin, have been synthesized in good yields using different methodology to achieve high purity then carboplatin was synthesized from reaction of prepared ligand with cisplatin. purity of prepared carboplatin was confirmed by high-performance liquid chromatography (hplc). platinum(ii) complex carboplatin, have been characterized with 1h and 13c nuclear magnetic resonance spectra and infrared spectroscopy.
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کلیدواژه
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3- cyclobutane dicarboxylic acid ,platinum complexes ,carboplatin ,anticancer
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آدرس
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university of tehran, university college of science, school of chemistry, ایران, university of tehran, university college of science, school of chemistry, ایران, university of tehran, university college of science, school of chemistry, ایران, university of tehran, university college of science, school of chemistry, ایران
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Authors
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