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Improved Synthesis of Vasicinone
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نویسنده
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- - ,- - ,- - ,- -
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منبع
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iranian journal of chemistry and chemical engineering - 2004 - دوره : 23 - شماره : 2 - صفحه:33 -36
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چکیده
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A new, high yielding method for the preparation of vasicinone (7) is described. reaction of 2-nitrobenzoic acid with n, n¢-carbonyldiimidazole followed by 2-pyrrolidinone gave 1-(2-nitrobenzoyl)pyrrolidine-2-one (3). reduction of the latter with 10% pd-c afforded deoxyvasicinone (4). reaction of deoxyvasicinone (4) with bromine yielded monobromo-deoxyvasicinone (5). exchange of bromine of 5 with acetoxy followed by hydrolysis gave vasicinone in high yield.
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کلیدواژه
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Vasicinone ,Synthesis ,Monobromodeoxyvasicinone ,Acetylvasicinone
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آدرس
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Department of Medicinal Chemistry and Pharmaceutic, Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center , Faculty of Pharmacy, Tehran University of Medical Sciences, P O Box 14155-6451, Tehran, I R IRAN, ایران, Department of Medicinal Chemistry and Pharmaceutic, Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center , Faculty of Pharmacy, Tehran University of Medical Sciences, P O Box 14155-6451, Tehran, I R IRAN, ایران, Department of Medicinal Chemistry and Pharmaceutic, Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center , Faculty of Pharmacy, Tehran University of Medical Sciences, P O Box 14155-6451, Tehran, I R IRAN, ایران, Department of Medicinal Chemistry and Pharmaceutic, Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center , Faculty of Pharmacy, Tehran University of Medical Sciences, P O Box 14155-6451, Tehran, I R IRAN, ایران
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پست الکترونیکی
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ashafiee@ams.ac.ir
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Authors
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