synthesis, characterization, and antibacterial activity evaluation of some new benzoxazepindiones obtained from diphenylacrylimidamides

This study reports the synthesis of new 1,3-oxazepine derivatives (s21-s30) by reacting hydrazones (schiff bases) (s11-s20) with phthalic anhydride in dry benzene as the solvent. the hydrazones were prepared by reacting diphenyl acrylamide derivatives (s1-s10) with para-chloroaniline using ethanol as the solvent. the acrylamides were derived from para-substituted acetanilides treated with various para-benzaldehydes using ethanol as the solvent. all synthesized compounds have been characterized using uv-visible and ft-ir spectroscopy. the structure of chemicals has been confirmed using proton and carbon nuclear magnetic resonance spectroscopy (1h-nmr and 13c-nmr). the purity of the synthesized chemicals was confirmed through thin-layer chromatography (tlc). the antibacterial activity of the new compounds has been assessed against gram-positive bacteria (streptococcus pneumoniae and staphylococcus aureus) and gram-negative bacteria (pseudomonas aeruginosa and escherichia coli).  the results showed significant antimicrobial activity at varying concentrations, with compounds s23, s26, and s30 exhibiting the highest effectiveness attributed to the electron-withdrawing halogens present in their structures.