determination of cytotoxicity, biological effects and anti-human breast cancer properties of bilobol

The current research used bilobol to determine the cytotoxicity and anti-human breast cancer properties with molecular docking studies. the properties of bilobol against breast cell lines i.e. hs578t, mda-mb-231, skbr3, bt-549, mcf-7, au565, 600mpe, and evsa-t were evaluated in the in vitro condition. the ic50 of the bilobol was 258, 236, 161, 265, 250, 183, 256, and 233 µm against mda-mb-231, hs578t, skbr3, bt-549, mcf-7, au565, evsa-t, and 600mpe, respectively. the molecular modeling evaluation analyzed the chemical effects of bilobol against alpha-amylase and alpha-glucosidase. the anti-cancer activities of the molecules were examined against mda-mb-231, hs578t, skbr3, bt-549, mcf-7, au565, evsa-t, and 600mpe cell lines. following completion of clinical trial research, the novel compound may find application in human supplementation against breast cancer. bilobol’s ic50 values for the enzymes α-amylase and α-glucosidase were found to be 45.13 and 11.82 µm, respectively. in the aforementioned cell lines, bilobol’s chemical interactions with a few expressed surface receptor proteins (egfr, cd47, androgen receptor, folate receptor, her2, cd44, progesterone receptor, and estrogen receptor) were determined using molecular modeling calculations. the outcomes displayed the likely atomic-level interactions and their properties. according to the docking scores, this chemical has a high affinity for certain proteins and enzymes. additionally, this substance made strong contact with the receptors and enzymes. as a result, both enzymes and cancer cells may be inhibited by this chemical molecule.