synthesis and characterization of targeted magnetic bentonite nanohybrid for enhanced drug delivery: a promising approach for cancer therapy

The use of smart materials to deliver anticancer drugs to tumors has been considerably increased in cancer therapy. in this work, a novel ph-responsive system for drug delivery is proposed that employs magnetite nanoparticles and bentonite loaded with doxorubicin (dox), a known anticancer drug, to investigate its loading capacity and release. this magnetic bentonite nanohybrid is first synthesized using a single-step method. the structural and spectral properties of the nano-assemblies are analyzed employing a variety of analytical methods including fourier transform infrared (ft-ir) spectroscopy, scanning and transmission electron microscopy (sem and tem, respectively), x-ray diffraction (xrd), and vibrating sample magnetometer (vsm). the drug-loading capacity, entrapment, and yield are compared with different ratios of 1:1, 1:2, and 1:4 of the drug: nanohybrid to choose the best ratio. moreover, a ph-sensitive release is measured at ph 7.4 and 5.5 with a total release of 57% and 80% after 72 h, respectively. considering all these findings, the magnetic bentonite shows significant promise as a potential candidate for drug delivery applications targeting cancer cells.