two new cholinesterase inhibitory and antioxidative constituents from syzygium cumini

Phytochemical investigation on dichloromethane (ch2cl2) fraction from fruit seeds of syzygium cumini provided two new esters syzygioate a (1) and syzygioate b (2), along with known compounds dipropyl succinate and dioctyl phthalate. the isolated compounds were characterized via spectroscopic techniques such as 1h, 13c nmr, ei-ms spectrometry, and ft-ir. the bioassay studies were also conducted for the isolated compounds where the new compound 1 and 2 exhibited significant inhibition potential against acetylcholinesterase (ache), butylcholinesterase (bche) antioxidant activity against diammonium 2,2’- azino -bis (3-ethyl benzo thiazoline-6-sulfonic acid (abts), superoxide anion radical scavenger 2,2-di phenyl-1-picryl hydrazyl (dpph). the ic50 values of compounds 1 and 2 for their cholinesterase inhibition were 7.15, 4.54µm against ache, and 9.21 6.31µm against bche. the dpph radical scavenging potential for compounds 1 2 exhibited ic50 values as 69.4µg/ml and 74.6µg/ml respectively.