synthesis and in silico studies of novel potent kinase inhibitors: 3-indoloylquinoline alkaloid

An exclusive approach towards the synthesis of indoylquinoline alkaloids has been illustrated, the present article describes the synthesis, in platelet-derived growth factor receptor and silico molecular docking studies of a new compound 3-indolylquinoline-2,4-diol 4. the synthesis of 4 is initiated by a new, efficient, and solvent-free via a thermal claisen condensation. the structures of the compounds are established using both spectral and analytical data. an in-silico pass, swiss adme-assisted docking approach is found to be suitable for deriving and synthesizing effective receptor tyrosine kinase agents. claisen ester condensation reaction resulted in the discovery of inexpensive and user-friendly solvents. structures of the newly synthesized compounds were characterized by ft-ir, 1h nmr, 13c nmr, and hrms (ftms+pesi) analyses.