investigation of flutamide@ethyleneimine as drug carrier by nanocone and nanotube theoretically

Flutamide is used with a luteinizing hormone-releasing hormone agonist, a type of hormonal injections such as leuprolide, goserelin, or triptorelin to treat certain types of prostate cancer. flutamide is in a class of medications called nonsteroidal antiandrogens. ethyleneimine  is used in polymerization products; as a monomer for polyethyleneimine; as a comonomer for polymers and in paper and textile chemicals, adhesives, and binders. this study applied ethyleneimine to modify flutamide as an anti-cancer drug. therefore, an investigation of the adsorption behavior and electronic properties of carbon nanotubes and nanocones against flutamide @ ethyleneimine was carried out by calculation of the density functional theory. the n atom of flutamide @ ethyleneimine helps its adsorption on the nanotubes and nanocones, showing adsorption energies of around - 30.1 and - 20.5 kcal/mol, correspondingly. chemical activities of the nano complexes were specified through electronic parameters such as electronegativity, electron affinity, softness, and hardness. all calculated data obtained good behavior of flutamide @ ethyleneimine with nanotubes and nanocones adsorption as carriers.