dibutyltin(iv) complex of 2-[(e)-(4-hydroxy-3-{(e)- [(quinolin-2-yl)imino] methyl} phenyl) diazenyl]benzoic acid: synthesis, spectroscopy and in vitroantifungal activity

Dibutyltin(iv) complex of 2-[(e)-(4-hydroxy-3-{(e)-[(quinolin-2-yl)imino] methyl} phenyl) diazenyl]benzoic acid was synthesized by refluxing 2-[(e)-(4-hydroxy-3-{(e)-[(quinolin-2- yl) imino] methyl} phenyl) diazenyl]benzoic acid with dibutyltin(iv) oxide in hot toluene. the complex was characterized by elemental analysis in combination with uv-visible, ir, 1h, 13c, 119sn nmr spectroscopy, and mass spectrometry technique. the carboxylate ligand acts as a chelating bidentate mode of coordination with the tin atom in the complex. the complex exhibited a cyclic dimeric structure in the solution state where the tin centers adopt 6- coordinate octahedral geometry. the in vitro antifungal property of the ligand and the complex was observed and compared with the reference drug, amphotericin-b.