>
Fa   |   Ar   |   En
   synthesis of thiophene-based flavone schiff base derivatives and a comparison of biological activities with furanflavone analogs  
   
نویسنده bollikolla hari babu ,khandapu bala murali krishna ,anandam rambabu ,uppalapati anitha ,rao saketi jagan mohana
منبع iranian journal of chemistry and chemical engineering - 2022 - دوره : 41 - شماره : 8 - صفحه:2616 -2627
چکیده    In this investigation, a series of thiophene-based flavone schiff base derivatives were synthesized starting from phloroglucinol. initially, the acetophenone derivative of phloroglucinol, 2-hydroxy-4,6-di-o-methyl phloroglucinol (3) was prepared by acetylation followed by selective o-methylation. later, compound 3 was condensed with thiophenealdehyde to obtain respective thiophene chalcone and was cyclized with i2/dmso to get the corresponding thiophene-based flavones intermediate. in the final stage, the titled schiff base derivatives were obtained by formulation at the 8th position of the flavone skeleton followed by condensation with various amines. all the synthesized compounds were tested for their antibacterial and anticancer activities. among the tested compounds, compound 8h (3-cl, 4-no2) showed good to excellent antibacterial activity on four microorganisms. further, the compounds were compared with corresponding schiff’s base analogs of furan-flavone schiff’s bases.
کلیدواژه thiopheneflavones ,5-memberedheterocyclic aldehydes ,schiff bases ,anticancer ,antibacterial
آدرس acharya nagarjuna university, department of chemistry, india, acharya nagarjuna university, department of chemistry, india, acharya nagarjuna university, department of chemistry, india, acharya nagarjuna university, department of chemistry, india, acharya nagarjuna university, department of chemistry, india
پست الکترونیکی jagan.saketi@gmail.com
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved