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   preparation, in-vitro evaluation, and delivery of colchicine via polyacrylamide hydrogel  
   
نویسنده liu huan ,wang yangying ,li yangyang ,wang min ,yu rui ,meng fanjun ,huang jinling ,li xiaoxia
منبع iranian journal of chemistry and chemical engineering - 2022 - دوره : 41 - شماره : 8 - صفحه:2595 -2606
چکیده    Hydrogels have excellent biocompatibility and are widely used in biomedical applications. however, it is still a challenge to build a hydrogel with outstanding mechanical properties and multiple functions. in this study, a polyacrylamide (pam) hydrogel with a uniform network structure was achieved through an ultraviolet (uv)-responsive organic crosslinking agent and a higher mechanical strength pam-ag+ hydrogel was designed through the introduction of silver ion by metal coordination interaction. various contents of n’n-bis(acryloyl)cysteamine (baca)  as cross-linker, acrylamide (am) as a monomer, and irgacure 2959 as initiator were investigated to have an optimal combination of high strength. thus, the pam-ag+ hydrogel exhibited excellent adhesive behavior that could be fixed to the human forearm and any part of the skin, such as the finger and elbow joint. in addition, the properties and biocompatibility evaluations of the tough hydrogel in medical wound dressing were investigated. meanwhile, these results showed that pam-ag+ hydrogels possess high stretchable (2600%) and mechanical robust (2.55 mpa) properties. excitingly, the release of colchicine (col) of more than 95% in 48 h demonstrated the hydrogel’s high potential in medical dressing and drug release applications by virtue of the excellent moisture retention, permeability, water tightness, swelling ratio, and biocompatibility.
کلیدواژه hydrogels ,high mechanical strength ,medical dressing ,drug release
آدرس anhui university of chinese medicine, the college of pharmacy, china, anhui university of chinese medicine, the college of pharmacy, china, the fourth affiliated hospital of anhui medical university, department of general surgery, china, anhui university of chinese medicine, the college of pharmacy, china, anhui university of chinese medicine, the college of pharmacy, china, anhui university of chinese medicine, the college of pharmacy, china, anhui university of chinese medicine, the college of pharmacy, china, anhui university of chinese medicine, the college of pharmacy, china
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