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dabco-catalyzed easy access to benzo[d]naphtho[2,3-g][1,3]-oxazocine‑8,13(6h,14h)‑diones in aqueous media
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نویسنده
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madani qamsari fatemeh ,moradi shahram ,foroumadi alireza ,mahdavi mohammad ,moghimi abolghasem
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منبع
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iranian journal of chemistry and chemical engineering - 2021 - دوره : 40 - شماره : 2 - صفحه:437 -443
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چکیده
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An eco-friendly, highly efficient, and tandem reaction between 2-hydroxy-1,4-naphthoquinone and quinolinium salts in the presence of dabco, 1,4-diazabicyclo[2.2.2]octane, in aqueous medium is developed for the synthesis of functionalized polycyclic naphthooxazocines. the advantageous features of this operationally simple procedure along with good to excellent yields of products highlighted this method for the preparation of oxazocine. moreover, the products obtained without the need to column chromatography. in order to reduce the hazards of chemicals and solvents, the reaction was conducted in the green solvent, water. all newly synthesized compounds were characterized by different methods involving ir, 1h nmr, 13c nmr spectroscopy.
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کلیدواژه
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naphthooxazocines ,dabco ,aqueous media ,environmentally benign
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آدرس
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islamic azad university, tehran north branch, department of chemistry, iran, islamic azad university, tehran north branch, department of chemistry, iran, tehran university of medical sciences, faculty of pharmacy & drug design and development research center, institute of pharmaceutical sciences (tips), department of medicinal chemistry, iran, tehran university of medical sciences, endocrinology and metabolism research center, endocrinology and metabolism clinical sciences institute, iran, imam hossein university, department of chemistry, iran
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پست الکترونیکی
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samoghimi@yahoo.com
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Authors
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