optimized method for curcumin separation from turmeric oleoresin

In this work, a novel and modified method for the solvent purification of curcumin is presented, a composite of normal hexane & 2-propanol solvents was used to separate the fat content and other impurities. the process was modeled considering the response surface methodology as described by the central composite design. the adjusted r-squared was 0.9443 indicating the variation between the regressors (solvent composition, solvent-to-oleoresin ratio, and temperature) in relation to the selected responses (product purity and process yield) were well described by the constructed model. optimum conditions were 90% w/w 2-propanol in the solvent, 1.5 solvent-to-oleoresin weight ratio and 5°c temperature with predicted 95.94% purity and 35.77% yield, f values were significant for both models. therefore, the development of high purity products is achievable with this novel method with economic advantages.