pseudo-five-component condensation for the diversity-oriented synthesis of novel indoles and quinolines containing pseudo-peptides (tricarboxamides)

A novel series of indole and quinoline tricarboxamides were synthesized using simple and efficient one-pot pseudo-five-component reactions of 2-formylindole or 2-chloro-3-formyl quinolines, isocyanides, amines, and meldrum’s acid as a ch-acid in ch2cl2 at room temperature. this conversion has been achieved via the construction of new bonds including two c-c bonds, two c-n bonds, and one c=o bond. remarkably, three peptide bonds were formed through a domino sequence including knoevenagel reaction, [1+4] cycloaddition, deacetonation and also, aminolysis reaction. particularly, a number of structurally remarkable and pharmacologically significant products were provided in excellent yields.