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Enantioselective Extraction of Ofloxacin Enantiomers Using Ester Alcohol L-Tartarate as Chiral Selector
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نویسنده
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Jiao Feipeng ,Chen Xiaoqing ,Jiang Xinyu
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منبع
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iranian journal of chemistry and chemical engineering - 2009 - دوره : 28 - شماره : 1 - صفحه:7 -11
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چکیده
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The distribution behavior of ofloxacin enantiomers was examined in the aqueous and organic solvent of a two-phase system containing chiral selector l-tartarate. the effect of extraction equilibrium time, buffer ph, organic solvents and length of alkyl chain of l-tartarate onthe partition coefficients and enantioselectivity of racemic ofloxacin were investigated, respectively. the l-tartarate formed more stable complexes with r-ofloxacin than that with s-ofloxacin. the partition coefficients and enantioselectivity of racemic ofloxacin increased with increasing length of alkyl chain of l-tartarate. solvents showed a large influence on enantioselectivity and partition coefficients. optimum buffer ph was about 7 for separation of racemic ofloxacin by extraction.
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کلیدواژه
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L-tartarate ,Ofloxacin enantiomers ,Chiral extraction ,Partition coefficient ,Enantioselectivity.
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آدرس
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Central South University, School of Chemistry and Chemical Engineering, CHINA, Central South University, School of Chemistry and Chemical Engineering, CHINA, Central South University, School of Chemistry and Chemical Engineering, CHINA
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پست الکترونیکی
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xqchen@mail.csu.edu.cn
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Authors
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