the role of aerobic training with the vaccinium arctostaphylos l. fruit hydro-alcoholic extract in the regulation of oxidative stress in the heart tissue of diabetic rats

Background: cardiovascular disease is a significant contributor to mortality in diabetic patients. despite the potential benefits of concomitant and complementary training in diabetic patients, there is a paucity of evidence in this area.aim: the objective of this study was to investigate the effect of aerobic training in conjunction with a hydroalcoholic extract of the fruit of qaraqat on superoxide dismutase, glutathione peroxidase, total antioxidant capacity, and malondialdehyde in the heart tissue of male rats with type 2 diabetes.materials and methods: 24 male rats aged 8 weeks were diabetic with a high-fat diet (60%) and streptozotocin injection. they were randomly divided into four groups: (1) aerobic training (at), (2) supplementation (sup), (3) aerobic training+ supplement (at+sup), and (4) diabetes control (con). the training protocol included running on a treadmill at a speed of 5-24 m/min for 10-60 min, according to the principle of overload. glucose, insulin, insulin resistance, and mda, tac, gpx, and sod of heart tissue were measured. statistical tests of two-way variance and post hoc bonferroni were used using spss software at a significance level of p<0.005.results a significant decrease in glucose levels, insulin resistance, and mda (p<0.005) was observed in the intervention groups following eight weeks of training and supplement intervention, in comparison to the con group. also, the amount of insulin in sup and at+sup groups exhibited a notable decline in comparison to con and at groups (p<0.005), as well as a substantial increase in the levels of sod (p=0.001) and gpx (p<0.005), and tac (p<0.005) was observed.conclusion: diabetes is associated with elevated mda levels, which are reduced by aerobic training and supplementation. furthermore, the administration of a training intervention and the utilization of a supplement have been demonstrated to elevate the levels of sod, tac, and gpx.