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In vitro Antiplasmodial Properties of Selected Plants of Sabah
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نویسنده
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Khozirah S. ,Noor Rain A. ,Siti Najila M.J. ,Imiyabir Z. ,Madani L. ,Rohaya C. ,Rosilawati M. ,Nuziah H. ,Goh S.H. ,Zakiah I.
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منبع
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pertanika journal of science and technology - 2011 - دوره : 19 - شماره : 1 - صفحه:11 -17
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چکیده
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The antiplasmodial activity of the crude extracts of thirty plant species collected from sabah was evaluated using chloroquine-sensitive strain (d10) and chloroquine-resistant strain (gombak a) of plasmodium falciparum. significant activities were observed for the bark extract of polyalthia insignis (ic50 3.89 and 11.89 mg/ml against gombak a and d10, respectively), the leaf extracts of kopsia dasyrachis (4.62 mg/ml against gombak a) and litsea elliptibacea (ic50 8.88 mg/ml against gombak a), as well as the leaf and bark extracts of neouvaria acuminatissima (ic50 6.90-10.08 and 0.69 mg/ml against gombak a and d10, respectively), and the bark extract of polyalthia microtus (ic50 9.0 and 12.12 mg/ml against gombak a and d10, respectively)
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کلیدواژه
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Plasmodium falciparum ,lactate dehydrogenase assay ,Polyalthia insignis ,Kopsia dasyrachis ,Neouvaria acuminatissima ,antimalarial
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آدرس
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Universiti Putra Malaysia, Institute of Bioscience, Laboratory of Natural Products, Malaysia, Institute for Medical Research, Herbal Medicine Research Center, Kuala Lumpur, Institute for Medical Research, Herbal Medicine Research Center, Malaysia, Forest Research Center, Malaysia, Forest Research Center, Malaysia, Institute for Medical Research, Herbal Medicine Research Center, Malaysia, Institute for Medical Research, Herbal Medicine Research Center, Malaysia, Forest Research Institute of Malaysia (FRIM), Malaysia, Forest Research Institute of Malaysia (FRIM), Malaysia, Institute for Medical Research, Herbal Medicine Research Center, Malaysia
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پست الکترونیکی
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khozirah@yahoo.com.my
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Authors
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