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unravelling over-represented amino acids in protein structure of allergen proteins; a large-scale study
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نویسنده
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rahmani nassim ,ebrahimie esmaeil ,niazi ali ,allahyari fard najaf ,bambai bijan ,minuchehr zarrin ,ebrahimi mansour
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منبع
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journal of cell and molecular research - 2016 - دوره : 8 - شماره : 2 - صفحه:65 -70
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چکیده
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Allergens are proteins or glycoproteins which make widespread disorders that can lead to a systemic anaphylactic shock and even death within a short period of time. understanding the protein features that are involved in allergenicity is important in developing future treatments as well as engineering proteins in genetic transformation projects. a big dataset of 1439 protein features from 761 plant allergens and 7815 non-allergen proteins was constructed. thereafter, 10 different attribute weighting algorithms were utilized to find the key characteristics differentiating allergens and non-allergen proteins. the frequency of leu, arg and gln selected by different attribute weighting algorithms with more than 50% confidence, including attribute weighting by weight_info gain, weight chi squared, weight_gini index and weight relief. high amount of gln and low percentage of leu and arg discriminate plant allergens from non-allergens
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کلیدواژه
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plant allergens ,attribute weighting algorithms ,amino acid
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آدرس
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shiraz university, institute of biotechnology, ایران, shiraz university, institute of biotechnology, ایران. university of south australia, school of information technology and mathematical sciences, division of information technology, engineering and the environment, australia. flinders university, , faculty of science and engineering, school of biological sciences, australia. university of adelaide, schools of medicine, australia, shiraz university, institute of biotechnology, ایران, national institute of genetic engineering and biotechnology (nigeb), ایران, national institute of genetic engineering and biotechnology (nigeb), ایران, national institute of genetic engineering and biotechnology (nigeb), ایران, university of qom, department of biology and bioinformatics research group, ایران
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پست الکترونیکی
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mansour@future.edu
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Authors
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