Renin-Angiotensin A1166c Polymorphism and the Rrisk of Stroke

Stroke is the leading cause of death and disability in the world after the cancer and cardiovascular diseases. geneticfactors have main significance to got stroke. renin-angiotensin system contains candidate genes andpolymorphisms for causing stroke. there are reported associations between stroke and angiotensin ii type-1receptor g. 1166a > c polymorphism (rs5186). therefore in this study this association was investigated for the eastiranian population. this study is based on 201 stroke patients and 220 controls. to predict the genetic risk of strokeallele and genotype frequencies of angiotensin ii type-1 receptor rs5186 were analyzed in this population accordingto stroke subtypes, gender, age, hypertension, diabetes mellitus, high and low density lipoprotein and triglycerides.according to statistical analysis no significant difference was found between case and control groups. but therewere a significant relevance between total cholesterol and stroke (p = 0.037). in this population angiotensin ii type-1 receptor g. 1166a > c polymorphism did not increase the risk of stroke. the main reason for this study iscomplex nature of gene-environment interactions in the pathophysiology of this disease.