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Evaluation of Relationship Between Hnf1alpha and Glp1r Polymorphisms and Type 2 Diabetes
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نویسنده
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Sepahi Samaneh ,Jalal Razieh ,Toluinia Behnaz ,Asoodeh Ahamad ,Darvish Jamshid
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منبع
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Journal Of Cell And Molecular Research - 2013 - دوره : 5 - شماره : 2 - صفحه:54 -59
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چکیده
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The prevalence of type 2 diabetes mellitus (t2dm) is rising dramatically in the middle east, especially in the islamic republic of iran, but the genetic basis of type 2 diabetes in iran is poorly understood. polymorphisms of hepatocyte nuclear factor-1? (hnf-1?) and glucagon-like peptide-1 receptor (glp-1r) genes showed association with type 2 diabetes in several ethnic groups. in this study, we evaluated whether these markers confer susceptibility to t2dm in a diabetic population living in mashhad (northeast of iran). genotyping of ala98val (hnf-1?) and thr149met (glp-1r) was done by the restriction fragment length polymorphism-pcr (rflp-pcr) method in the following groups: 1) early-onset diabetes (age at onset ? 35 years); 2) late-onset diabetes (age at onset > 35 years); and 3) control. our results showed that ct (ala/val) genotype of hnf-1? was higher in the early-onset type 2 diabetic group compared to the controls but difference was not significant. we did not find the glp-1r thr149met mutation in all participants. the prevalence of the hnf-1? (ala98val) and (glp-1r) thr149met mutations has not been previously reported in iranian participants. we conclude that these mutations are not a common cause of t2dm in our studied population.
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کلیدواژه
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Type 2 Diabetes ,Hepatocyte Nuclear Factor-1alpha ,Glucagon-Like Peptide-1 Receptor ,Polymorphism
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آدرس
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Ferdowsi University Of Mashhad, ایران, Ferdowsi University Of Mashhad, ایران, Ferdowsi University Of Mashhad, ایران, Ferdowsi University Of Mashhad, ایران, Ferdowsi University Of Mashhad, ایران
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Authors
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