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   microrna binding site polymorphisms are associated with the development of gastric cancer  
نویسنده asgarpour jamal ,mehrzad jamshid ,tabatabaei yazdi abbas
منبع journal of cell and molecular research - 2017 - دوره : 9 - شماره : 2 - صفحه:73 -77
چکیده    micrornas (mirnas) binding to the 3'-untranslated regions (3'-utrs) of messenger rnas (mrnas), affect several cellular mechanisms such as translation, differentiation, tumorigenesis, carcinogenesis and apoptosis. the occurrence of genetic polymorphisms in 3'-utrs of target genes affect the binding affinity of mirnas with the target genes resulting in their altered expression. the current case-control study of 100 samples (50% cancer patients and 50% health persons as control) was aimed to evaluate the genotyping of microrna single nucleotide polymorphisms (snps) located at the binding site of the 3'-utr of c14orf101 (rs4901706) and mir-124 (- rs531564) genes and their correlations with gastric cancer (gc) development. the statistical analysis results indicated the significant association of ag development risk with the snps located in the 3'-utr of c14orf101 and mir-124. it could be concluded from the results that these genes are associated with the gastric adenocarcinoma.
کلیدواژه carcinogenesis ,c14orf101 polymorphism ,mir124 ,gastric cancer development
آدرس islamic azad university, neyshabur branch, department of genetic, ایران, islamic azad university, neyshabur branch, department of biochemistry, ایران, mashhad university of medical sciences, department of pathology, ایران
پست الکترونیکی tabatabaeea@mums.ac.ir

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