microrna binding site polymorphisms are associated with the development of gastric cancer

Micrornas (mirnas) binding to the 3'-untranslated regions (3'-utrs) of messenger rnas (mrnas), affect several cellular mechanisms such as translation, differentiation, tumorigenesis, carcinogenesis and apoptosis. the occurrence of genetic polymorphisms in 3'-utrs of target genes affect the binding affinity of mirnas with the target genes resulting in their altered expression. the current case-control study of 100 samples (50% cancer patients and 50% health persons as control) was aimed to evaluate the genotyping of microrna single nucleotide polymorphisms (snps) located at the binding site of the 3'-utr of c14orf101 (rs4901706) and mir-124 (- rs531564) genes and their correlations with gastric cancer (gc) development. the statistical analysis results indicated the significant association of ag development risk with the snps located in the 3'-utr of c14orf101 and mir-124. it could be concluded from the results that these genes are associated with the gastric adenocarcinoma.