Study on the potency of Domperidone and Metoclopramide for spawning induction in Kutum (Rutilus frisii kutum).

The effectiveness of two kinds of dopamine antagonist (da),metoclopramide (met) and domperidone (dom) combined with the gonadotropin releasing hormone analogue (d_ala6 , des gly10 ethylamide) gnrha was assayed on the ovulation success, latency period, ovulation index (01) and fertilization success of kutum, rutilus frisii kulum (kamenskii, 1901). broodfish were injected intraperitoneallyas follows: 2 mg/kg b.w. of carp pituitary extract (cpe) as a control, 5(mu)g + 2.5mg, 10(mu)g + 5mg and 20(mu)g + 10mg/kg b.w. of gnrha + met or dom in a single injection. based on the ovulation and fertilization success, no significant differences between similar doses of dom and met when combined with similar doses of gnrha were found (p>0.05). however, in some groups, the 01 and latency period were greater when dom was used as a da instead of met (p<0.05). in general, the results of this study showed that the potency of dom was nearly same as met when combined with gnrha and used as a da in kutum. it is strongly recommended to repeat the experiment under different conditions to find out definite conclusion.