association of insulin-like growth factor-1 gene single nucleotide polymorphism rs10860860 with type 2 diabetes

Aims: one extremely important public health challenge worldwide is diabetes mellitus. type 2 diabetes mellitus is a rising concern around the globe. early revealing of type 2 diabetes mellitus is very significant in that morbidity associated with the condition can be decreased. studies have proposed that insulin-like growth factor-1 has roles similar to that of insulin. the existing study was implemented to reveal the alliance of single nucleotide polymorphism rs10860860 of the igf-1 gene with type 2 diabetes mellitus. materials & methods: this case-control study was conducted in merjan hospital in babylon province, iraq, in 2022. the available random sampling method selected two groups of healthy individuals (n=50 as control) and type 2 diabetes mellitus patients (n=158 as study). the serum levels of glucose and zinc were determined by spectrophotometric method. the serum igf-1 level was estimated using the sandwich elisa technique. the students’ t and chi-square tests were used to assess data in spss 21 software. findings: the different levels of glucose, zinc, and igf-1 were significant between the two groups. genotyping frequencies of the igf-1 gene deviated from hardy weinberg equilibrium in the control group (χ2=9.158; p=0.002) while were consistent in the study group (χ 2=2.482; p=0.115). the at genotype was associated with lower odds of type 2 diabetes mellitus than those of the wild genotype aa. conclusion: the at genotype of igf-1 gene snp rs10860860 negatively associates with type 2 diabetes mellitus.