comparison of visfatin and leptin levels in type 2 diabetic patients with and without atherosclerosis

Aims: medical evidence shows that visfatin and leptin are related to multiple metabolic problems, including obesity, type 2 diabetes, and cardiovascular disease. the present study aimed to assess visfatin and leptin levels in type 2 diabetic patients with and without atherosclerosis.instruments & methods: this descriptive study was conducted on 30 diabetic patients, 30 patients with diabetes mellitus and atherosclerosis, and 30 seemingly healthy persons (as a control group) in babylon province, iraq, and their serum visfatin and leptin levels were assessed by elisa procedure. the statistical analysis was done with spss 21 software.findings: in diabetic patients and patients with diabetes and atherosclerosis, the level of visfatin was significantly higher than in the control group (p=0.0001). there was a significant increase in leptin level in diabetic patients compared to the control group (p=0.0001), while leptin level showed a significant decrease in patients with diabetes and atherosclerosis than in the control group (p=0.0001). also, the mean body mass index in diabetic patients and patients with diabetes and atherosclerosis was significantly higher than in the control group (p=0.0001).conclusion: visfatin serum levels are significantly higher in atherosclerosis patients compared to healthy people, while low leptin and high visfatin expression are seen in patients with diabetes.