association of atp-binding cassette transporter a1 (abca1)-565 c/t gene polymorphism with hypoalphalipoproteinemia and serum lipids, il-6 and crp levels

Background: atp-binding cassette transporter a1 (abca1) is a membrane integral protein which plays a vital role in high density lipoprotein (hdl) metabolism and exerts a protective effect against hypoalphalipoproteinemia (ha) by mediation of rate-limiting step in hdl biogenesis. in addition, this protein possesses anti-inflammatory effects by inhibiting the production of some inflammatory cytokines in macrophages. this study investigated the association of abca1-565 c/t gene polymorphism with ha and serum lipids, il-6 and crp levels. methods: a population which consisted of 101 ha and 95 normal subjects were genotyped for abca1-565c/t polymorphism by polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp). the serum concentrations of lipids, il-6 and high sensitive-crp (hs-crp) were measured by the relevant methods. results: the frequency of t allele was significantly higher in the ha group than the controls (31.7 vs. 19.5%, p=0.002). thus, carriers of the t allele (ct and tt genotypes) had a higher risk for ha (p=0.016, or=2.04, 95% ci=1.14-3.63). t allele carriers demonstrated decreased hdl-c and increased triglyceride, il-6 and crp levels than those with the cc genotype. conclusion: this study suggests that the-565 c/t polymorphism of abca1 gene is associated with an increased risk of ha, decreased hdl-c and increased tg, il-6 and crp.