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Use of Raman Spectroscopy to Decrease Time for Identifying the Species of Candida Growth in Cultures
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نویسنده
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Chouthai Nitin S. ,Shah Anuj A. ,Salimnia Hossein ,Palyvoda Olena ,Devpura Suneetha ,Klein Michael ,Asmar Basim
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منبع
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avicenna journal of medical biotechnology - 2015 - دوره : 7 - شماره : 1 - صفحه:45 -48
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چکیده
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background: the objective of this study is to establish raman signatures from pure cultures of different candida species using raman spectroscopy (rs) and use these signatures for rapid identification of unknown candida species. methods: pure cultures of five candida species were evaluated using rs to build a limited signature library. ‘raman processing’ (rp) software was used for principal component analysis (pca) and differential functional analysis (dfa). results: eleven principal components described at least 95% variance in the spectra. raman signatures from these known candida species were able to identify the species of unknown candida cultures with 100% accuracy. conclusion: raman spectroscopy can improve early identification of candida species and may facilitate early optimal antifungal therapy.
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کلیدواژه
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Candida species ,Raman ,Spectrum analysis
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آدرس
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Wayne State University, Division of Neonatal-Perinatal Medicine, USA, Wayne State University, Division of Neonatal-Perinatal Medicine, USA, Wayne State University, Division of Pathology, USA, Wayne State University, Lumigen Instrument Center, USA, Henry Ford Health System, Department of Radiation Oncology, USA, Wayne State University, Pediatric Surgery, USA, Wayne State University, Division of Pediatric Infectious Diseases, USA
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Authors
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