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Effects of Combined Soy Isoflavone Extract and Docetaxel Treatment on Murine 4t1 Breast Tumor Model
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نویسنده
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Hejazi Ehsan ,Nasrollahzadeh Javad ,Fatemi Ramina ,Barzegar-Yar Mohamadi Leila ,Saliminejad Kioomars ,Amiri Zohre ,Kimiagar Masoud ,Houshyari Mohammad ,Tavakoli Maryam ,Idali Farah
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منبع
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Avicenna Journal Of Medical Biotechnology - 2015 - دوره : 7 - شماره : 1 - صفحه:16 -21
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چکیده
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background: emergence of drug resistance has brought major problems in chemotherapy. using nutrients in combination with chemotherapy could be beneficial for improvement of sensitivity of tumors to drug resistance. soybean-derived isoflavones have been suggested as chemopreventive agents for certain types of cancer, particularly breast cancer. in this study, the synergistic effects of soy isoflavone extract in combination with docetaxel in murine 4t1 breast tumor model were investigated. methods: in this study, mice were divided into 4 groups (15 mice per group) of control, the dietary soy isoflavone extract (sie, 100 mg/kg diet), the docetaxel (doce, 10 mg/kg) injection and the combination of dietary soy isoflavone extract and intravenous docetaxel injection (doce+sie). after 3 injections of docetaxel (once a week), 7 mice were sacrificed to analyze mki67 gene and protein expressions and the rest were monitored for diet consumption, tumor growth and survival rates. results: in doce+sie group, diet consumption was significantly higher than doce group. while lifespan showed a trend towards improvement in doce+sie group, no significant difference was observed among the 4 studied groups. tumor volume was not significantly affected in treated groups. a lower but not significant mki67 protein expression was detected in western blot in doce+sie group. the mrna expression was not significantly different among groups. conclusion: the results suggest that the combination of soy isoflavone as an adjunct to docetaxel chemotherapy can be effective in improving diet consumption in breast cancer.
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کلیدواژه
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Breast Cancer ,Docetaxel ,Soy Isoflavone Extract
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آدرس
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Shahid Beheshti University Of Medical Sciences, School Of Nutrition Sciences And Food Technology, Department Of Clinical Nutrition And Dietetics, ایران, Shahid Beheshti University Of Medical Sciences, School Of Nutrition Sciences And Food Technology, Department Of Clinical Nutrition And Dietetics, ایران, Acecr, Avicenna Research Institute, Reproductive Immunology Research Center, ایران, Acecr, Avicenna Research Institute, Monoclonal Antibody Research Center, ایران, Acecr, Avicenna Research Institute, Reproductive Biotechnology Research Center, ایران, Shahid Beheshti University Of Medical Sciences, School Of Nutrition Sciences And Food Technology, Department Of Basic Sciences And Cellular And Molecular Nutrition, ایران, Shahid Beheshti University Of Medical Sciences, School Of Nutrition Sciences And Food Technology, Department Of Clinical Nutrition And Dietetics, ایران, Shahid Beheshti University Of Medical Sciences, Shohada Tajrish Hospital, Department Of Radiation Oncology, ایران, Acecr, Avicenna Research Institute, Reproductive Immunology Research Center, ایران, Acecr, Avicenna Research Institute, Reproductive Immunology Research Center, ایران
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Authors
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