Formulation, Characterization, and Evaluation of Wound Healing Potency of a Novel Mattan tailam Nanogel Based on a Famous Traditional Siddha Formula

Background: the mattan tailam mixture has been extensively used to heal ulcerous wounds in traditional siddha practice. the present study aimed to synthesize a mattan tailam nanogel and evaluate the enhancement of wound healing potential in an experimental wound model. methods: mattan tailam nanogel was synthesized using the high-energy milling approach, and characterization of nanogel and potency of wound healing was investigated. the novelty of this study was the nanogel preparation of mattan tailam. results: as expected, a synthesized novel nanogel of mattan tailam has a distinct, prominent peak with a spherical form, is negatively charged and has an average particle size of 20–30 nm. mattan tailam nanogel treated rats showed a remarkable reduction (p<0.001) in the wound area. on the 16th day, 10% mattan tailam nanogel treatment resulted in a higher percentage of wound contraction. the 10% mattan tailam nanogel group exhibited a faster epithelialization time (14.33 days) and a greater hydroxyproline concentration than the others. the topical application of 10% mattan tailam nanogel increased tensile strength, signifying a better therapeutic indication. conclusion: the present findings prove that polyherbal mattan tailam nanogel formulation significantly improves collagen production, wound contraction, and tensile strength.