Antibiotic Resistance Pattern in Pseudomonas aeruginosa Isolated from ClinicalSamples Other than Burn Samples in Iran

Background: the purpose of this study was to systematically review the prevalence ofclass 1 integrons, antibiotic resistance pattern in pseudomonas aeruginosa (p. aeruginosa)isolated from clinical samples other than burn samples.methods: the web of science, pubmed, scopus, and science direct databases weresearched using keywords based on the preferred reporting items for systematic reviewand meta-analyses (prisma) guidelines. the cross-sectional studies publishedfrom 1st january 2000 until 1st january 2019 were included which addressed the prevalenceof class 1 integrons and antibiotic-resistance in p. aeruginosa isolated from clinicalsamples other than burn samples. meta-analysis was conducted using comprehensivemeta-analysis (cma) software. the random-effects model, cochran’s q andi2 tests were applied for statistical analyses.results: eight articles met the eligibility standards for including in the present metaanalysis.the combined prevalence of class 1 integrons in p. aeruginosa isolated fromclinical samples other than burn samples was reported by 40% (95% ci:26.1-55.8%).the pooled prevalence of multi-drug resistant (mdr) p. aeruginosa isolates was70.1%. the highest prevalence of combined antibiotic resistance was related to carbenicillinwith a resistance rate of 79.9%. in general, 6 (75%) out of the 8 includedstudies showed the correlation between the presence of class 1 integrons and antibioticresistance.conclusion: regarding the correlation between the presence of integrons and the highantibiotic resistance reported by studies included in the present review, there is theneed for preventive measures to prevent the spread of resistance by integrons andtransferring to other micro-organisms.