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Comparison of Antifungal Properties of Gold, Silver, and Selenium Nanoparticlesagainst Amphotericin B-Resistant Candida Glabrata Clinical Isolates
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نویسنده
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Lotfali Ensieh ,Toreyhi Hossein ,Makhdoomi Sharabiani Kamyab ,Fattahi Azam ,Soheili Amirali ,Ghasemi Reza ,Keymaram Mahyar ,Rezaee Yasaman ,Iranpanah Sayna
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منبع
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Avicenna Journal Of Medical Biotechnology - 2021 - دوره : 13 - شماره : 1 - صفحه:47 -50
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چکیده
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Background: the present study aimed to investigate the antifungal activity ofnanoparticles (nps) against amphotericin b-resistant candida glabrata (c. glabrata)strains.methods: twelve resistant (c. glabrata) strains were isolated from archived clinicalisolates. antifungal activity was conducted according to clinical and laboratorystandards institute’s (clsi) guidelines, document m27-a3/s4. the scanning electronmicroscope (sem) was used to observe the morphological changes of strains exposedto each nanoparticle.results: minimum inhibitory concentration (mic) of nanoparticles of all strains was inthe concentration range of 0.125 to 0.5 μg/ml. the synthesized ag-nps showed superiorantifungal activity against (c. glabrata) compared to se-nps and au-nps. thescanning electron microscope images revealed the difference in the fungal morphologybetween the untreated and treated fungi with nanoparticles.conclusion: the ag-nps, followed by se-nps synthesized, revealed significant antifungalactivity against resistance regardless of their antifungal-resistant mechanisms.
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کلیدواژه
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Antifungal Agents ,Candida Glabrata ,Nanoparticles ,Silver
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آدرس
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Shahid Beheshti University Of Medical Sciences, Faculty Of Medicine, Department Of Medical Parasitology And Mycology, Iran, Shahid Beheshti University Of Medical Sciences, Student Research Committee, Faculty Of Medicine, Iran, Shahid Beheshti University Of Medical Sciences, Student Research Committee, Faculty Of Medicine, Iran, Tehran University Of Medical Sciences, Center For Research And Training In Skin Diseases And Leprosy, Iran, Shahid Beheshti University Of Medical Sciences, Student Research Committee, Faculty Of Medicine, Iran, Shahid Beheshti University Of Medical Sciences, Student Research Committee, Faculty Of Medicine, Iran, Iran University Of Medical Sciences, Faculty Of Medicine, Department Of Medical Parasitology And Mycology, Iran, Iran University Of Medical Science, Faculty Of Medicine, Department Of Medical Parasitology And Mycology, Iran, Shahid Beheshti University Of Medical Sciences, Student Research Committee, Faculty Of Pharmacy, Iran
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Authors
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