Effective Anti-SARS-CoV-2 RNA Dependent RNA Polymerase Drugs Based on Docking Methods: the Case of Milbemycin, Ivermectin, and Baloxavir Marboxil

Background: severe acute respiratory syndrome-coronavirus 2 (sars-cov-2) is a new virus with a global pandemic. yet, no vaccine or efficient treatments are found against the disease. the viral rna dependent rna polymerase (rdrp) is a suitable target for developing antiviral agents. sars-cov-2 rdrp was employed to test its binding activity with some drugs. methods: using some docking methods, rdrp was targeted by milbemycins (mms), ivermectin (imt), baloxavir marboxil (bm), and tadalafil (tf), a phosphodiesterase type 5 inhibitor. results: mm-a3 5-oxime (mma35o), mm-a3 (mma3), mm-a4 5-oxime (mma45o), imt, bm, and tf showed the highest binding affinity to rdrp. conclusion: the drugs used in the present computational investigation are effective against the sars-cov-2 rdrp with high affinity values especially, milbemycins, ivermectin, and baloxavir marboxil, which could further be studied in laboratory and clinical trials for saving millions of lives around the world.