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Host-Microbiota Interaction is MyD88-Independent in the Intestinal Tract under Physiologic Condition
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نویسنده
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Moossavi Shirin ,Rezaei Nima
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منبع
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avicenna journal of medical biotechnology - 2012 - دوره : 4 - شماره : 4 - صفحه:210 -211
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چکیده
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The role of microbiota in health and disease is the subject of rigorous investigation. sever- al studies have demonstrated that microbiota and the pattern-recognition receptors contrib- ute to intestinal tumourigenesis; the exact mechanism of which is still obscure. myd88 is the downstream effector of all toll-like re- ceptors (tlrs) except tlr3. however, the alternative myd88-independent pathway is functional downstream of not only tlr3, but also tlr1/2, 2/6, 4, and 5. tlr4 stimulation with intraperitoneal lipopolysaccharide exerts distinct functional effect on the intestinal mo- tility via myd88-dependent and-independent pathways.
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کلیدواژه
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Host-microbiota interaction ,Intestinal tract ,Toll-like receptors
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آدرس
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tehran university of medical sciences tums, Digestive Disease Research Center, ایران, tehran university of medical sciences tums, School of Medicine, Molecular Immunology Research Center and Department of Immunology, ایران. tehran university of medical sciences tums, Pediatrics Center of Excellence, Children's Medical Center, Research Group for Immunodeficiencies, ایران. University of Sheffield, School of Medicine and Biomedical Sciences, Department of Infection and Immunity, UK
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پست الکترونیکی
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rezaei_nima@tums.ac.ir
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Authors
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