Interleukin 10 and Transforming Growth Factor Beta Polymorphisms As Risk Factors For Kawasaki Disease: A Case-Control Study and Meta-Analysis

Background: alteration in serum expression of transforming growth factor-beta (tgf-β) and il-10 have been suggested to play a role in the pathogenesis of kawasaki disease (kd). inconsistent reports exist on the association of il-10 polymorphisms with kd susceptibility and coronary artery aneurysms (caa). methods: a number of 110 paediatric patients with kd and 140 healthy individuals were recruited to investigate the frequency of single nucleotide polymorphisms (snps) of tgf-β c/t at codon 10 (rs1982073), c/g at codon 25 (rs1800471) and il-10 a/g at -1082 (rs1800896), c/t at -819 (rs1800871) and a/c at -592 (rs1800872) and their respective genotype and haplotypes. a comprehensive search was performed in medline and scopus using the keywords of interleukin 10, transforming growth factor beta, and kawasaki disease. moreover, previous studies investigating the tgf- β and il-10 polymorphisms in kd were evaluated. review manager version 5.1 software was used to perform meta-analysis. results: there was no significant association between allelic or genotypic variants in the mentioned polymorphisms in tgf-β or il-10 with kd or caa. the only significant haplotypic variant was tc variant at codon 10, and 25 of tgf-β polymorphisms were associated with higher risk of kd. meta-analysis of a total number of 770 patients vs. 1471 healthy controls showed no difference in the frequency of any of the il-10 genetic variants in kd patients, regardless of the presence of caa. conclusion: polymorphisms of tgf-β or il-10 are not associated with additional risk for kd in iranian population. il-10 polymorphisms at -1082, -819 and -592 positions are not associated with kd, nor do they predict coronary artery aneurysm formation.