Investigation of the Association Between 5-Hydroxytryptamine Transporter Gene-Linked Polymorphic Region With Type 2 Diabetes Mellitus, Obesity and Biochemical Profiles of Serum in Iranian Population

Background: type 2 diabetes mellitus (t2dm) is a serious problem in the world. 5-hydroxytryptamine (5-ht, serotonin) plays an important role in obesity, glucose control and insulin resistance. the polymorphism of the serotonin transporter gene linked promoter region (5-httlpr) might influence 5-htt expression and serotonin uptake. the polymorphism results in two alleles of l (long) and s (short). the aim of the present study was to evaluate the association between 5-httlpr genotypes in type 2 diabetes mellitus (t2dm), obesity as well as serum biochemical profiles in iranian population from 2012 until 2015. methods: 180 patients with t2dm and 180 controls were selected and the frequency of s and l alleles was determined by pcr. then, the relationship between genotypes, body mass index (bmi) and serum biochemical variables was investigated. results: the frequency of s and l alleles in experimental and control groups was the same [for the l allele p=0.754, or (95%ci)=1.103 (0.597 to 2.041) and for the s allele p=0.906, or (95%ci)=(0.490 to 1.676)]. however, the mean triglyceride, cholesterol, ldl-c, systolic and diastolic blood pressure levels in the diabetic subjects with ll genotype were significantly higher than ls and ss genotypes (p<0.001) in this population. conclusion: the l allele of 5-httlpr was related to the increased serum lipids and blood pressure in the diabetic patients. however, there was no relationship between the polymorphism of 5-httlpr l/s and t2dm in iranian population.