The modulatory effect of CA1 5HT 4 receptors on memory acquisition deficit induced by harmaline

The plethora of studies indicated that there is a cross talk relationship between harmaline and serotonergic (5-ht) system on cognitive and non-cognitive behaviors. thus, the purpose of this study is assessment the effects of ca1 5-ht4 receptor on memory acquisition deficit induced by harmaline. harmaline was injected peritoneally, while 5-ht4 receptor agonist (rs67333) and antagonist (rs23597-190) were injected intra-ca1. for memory measurement,a single-trial step-down passive avoidance apparatus was used. the data revealed that pre-training injection of higher dose of harmaline (1 mg/kg), rs67333 (0.5 ng/mouse) and rs23597-190 (0.5 ng/mouse)decreased memory acquisitionprocess in the adult mice. moreover, concurrent pre-training administration of subthreshold doseof rs67333 (0.005 ng/mouse) orrs23597-190 (0.005 ng/mouse)with subthreshold dose of harmaline (0.5 mg/kg, i.p.)intensify impairment of memory acquisition. all above interventions did not change locomotion and tail flick behaviors. in conclusion, the results demonstrated that the synergistic effect between both ca1 5-ht4 receptor agonist and antagonist with impairment of memory acquisition induced by harmaline, indicating a modulatory effect for ca1 5ht4 receptor on harmaline induced amnesia