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Biomarker Profiling (Erbb2, P53, and PR) for Stage I of Breast Cancer
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نویسنده
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Rezaei-Tavirani Majid ,Zamanian-Azodi Mona ,Azizi-Jalilian Farid ,Khodakarim Soheila
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منبع
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archives of advances in biosciences - 2013 - دوره : 4 - شماره : 4 - صفحه:47 -50
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چکیده
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Breast cancer (bc) accounts for one of the major health problems around the world. since the diagnosis process can have great effect on therapy outcomes, we studied the biomarkers specific to breast tumors stage i based on examining different iranian patients. cases from different stages were examined to discover their highly expressed proteins. in addition, pathologic evaluations were performed as the diagnosis procedure. considering positive percentage of over-expressed protein in different stages in the population, it is guessed that over-expression of erbb2 and pr are positively correlated, while p53 is in negative correlation with them. therefore, these molecules can probably account for stage i biological marker. this study suggests that alterations in over-expression of specific biomarkers in different stages may be associated to the
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کلیدواژه
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Breast cancer ,Biomarker ,Detection ,Staging ,Treatment
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آدرس
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ilam university of medical sciences, Faculty of Medicine, ایران, shahid beheshti university of medical sciences, Proteomics Research Center, Faculty of Paramedical Sciences, ایران, ilam university of medical sciences, Department of Clinical Microbiology, Faculty of Medicine, ایران, shahid beheshti university of medical sciences, Department of Epidemiology, Faculty of Public Health, ایران
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Authors
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