Increased Plasma Levels of Soluble CD27 among HIV/HCV Co-infected and HIV/HCV/GBV-C Triply Infected Subjects.

Cd27 is a biomarker associated with both t-cells and b-cells activation .plasma soluble cd27 (scd27) was identified as a marker of disease outcome in human immunodeficiency virus (hiv) infection .testing of plasma scd27 represents a good tool to monitor the change of immune activation during hiv infection.we sought to analyses role of hepatitis c virus (hcv) and also gb virus type c (gbv-c) co-infections on hiv-related immune activation, through measuring scd27 plasma levels.blood samples from a total of 86 patients with hiv infection were taken. plasmas were analyzed for hcv using serologic test and gbv-c by reverse transcriptase polymerase chain reaction (rt-pcr). cd4+ and cd8+t-cell counts were evaluated by cd3/cd4+ and cd3/cd8+ double staining of whole blood followed by flow cytometric analysis .then cross-sectional comparison of scd27 plasma levels was carried out among patients : hiv (n=20), hiv/ gbv-c (n=14), hiv/ (hcv) (n=26) and hiv/hcv/gbv-c (n=26).plasma level of scd27 was higher in hiv/hcv/gbv-c patients as compared to hiv mono-infected patients (p= 0.006) and based on results there was significant differences in the plasma levels of scd27 between hiv-infected individuals with and without hcv coinfection (p=0.017) and also correlation between scd27 and percent of cd4+t-cells was in highest level among hiv/hcv co-infected patients group [r= -0.59 (p=0.001)]. high levels of scd27 among hiv/hcv patients argues in favor of scd27 plasma level determination for monitoring of clinical features among hiv/hcv coinfected patients.