neuroprotective effects of salvia hydrangea extract through dietary uptake in amyloid beta-injected rats

Introduction: alzheimerʼs disease (ad) has been identified as a progressive memory and cognitive impairment. some salvia species are suggested by certain studies for the management of mild to moderate ad. we aimed to evaluate the anti-inflammatory, antioxidant, and anti-apoptotic effects of s. hydrangea on amyloid beta-injected rats.materials and methods: rats were pretreated with s. hydrangea for 10 days before amyloid beta (aβ) injection. western blotting techniques were used to evaluate protein level of γ-glutamyl cysteine synthetase (γ-gcs), tumor necrosis factor α (tnf-α) and interleukin-6 (il-6) in two brain regions: hippocampus and frontal cortex.results: current data show that s. hydrangea extract increased γ-gcs protein levels in amyloid beta injected rats, and pretreatment with s. hydrangea increased it further. besides, s. hydrangea decreased protein levels of tnf-α and il-6 in amyloid beta injected rats.conclusion: based on the decreased levels of il-6, tnf-α, and the increased levels of γ-gcs, it is suggested that the use of s. hydrangea could be protective in neurodegenerative diseases.