anti-inflammatory activities of nannorrhops ritchieana (griff.) aitch inflorescence extract in an animal model

Introduction: given the use of n. ritchieana inflorescence (ner) in the folklore medicine of the south of iran for relieving inflammation and pain in inflammation-based disorders, the current study assessed the anti-inflammatory features of n. ritchieana inflorescence extract (nre) in animal models.materials and methods: the carrageenan-induced paw edema method was used to evaluate the acute anti-inflammatory effects of the nre extract (50,100, and 200mg/kg, i.p.). the postive and negative control groups received mefenamic acid and normal saline, respectively. then, the rats’ paw tissues were removed and collected for studying tumor necrosis factor (tnf-α) level. in addition, the cotton pellet-induced granuloma method was utilized to assess the chronic anti-inflammatory effects of the extract (100 and 200 mg/kg daily for 8 days, i.p.). the postive and negative control groups received indomethacin and saline, respectively. on the last day of the cotton pellet test, the rat’s serum was collected for interleukin-1 beta (il-1β) determination.results: in the carrageenan test, the extract significantly reduced the paw edema compared to that of the control (p<0.05). the anti-inflammatory activity (100 and 200 mg/kg) of the extract was similar to that of the mefenamic acid group (p<0.05). tnf-α levels demonstrated significant anti-inflammatory effects just at the dose of 200 mg/kg. in granuloma induced by cotton pellets, nre was also effective based on the granuloma formation and the transudate amount. the anti-inflammatory activity of the inflorescence extract was found to be the same as the indomethacin group, whereas il-1β did not represent significant changes.conclusion: according to the results, nre had a considerable anti-inflammatory effect