Internal Dosimetry of 99mtc-Androctonus Crassicauda Scorpion Venom Complex Using Mcnpx Simulation Code And Mird Method For Cancer Study

Introduction: natural toxins such as scorpion venom have been used to treat different diseases for many decades. radiolabeled toxins will help the researchers as a cancer diagnostic and therapeutic agent. the biodistribution of radionuclide-venom complex in animal organs and the internal dosimetry estimation are of great importance for the clinical purposes. materials and methods: in this study, the effective dose estimation was performed using mird analysis method and mcnpx simulation code. for this purpose, after obtaining the biological distribution results such as %id/g, accumulation activity of 99mtc-venom complex, the organs doses were calculated by the two aforementioned methods and human data were extracted from the sparks-idogan formula. stomach, heart wall, kidney, liver, lung, spleen, thyroid, intestine and brain were considered as source organs. results: the effective dose of 99mtc-venom in different organs of the human body was calculated based on the biodistribution in the rat body. the highest and the lowest effective dose delivered to the heart wall (with 3.47e-05 and 4.05e-05 msv/mbq) and the testic (0.05e- 06 and 0.08e-06 msv/mbq), respectively. conclusion: biodistribution of radiolabeled venom in animal organs indicates that the complex delivers the highest dose to the heart. also the results of the two dosimetry methods have an acceptable agreement