estimation of human absorbed dose of ^99mtc-maa using mird method based on animal data and comparison with mcnp simulation code

Introduction:^99mtc-macro aggregated-albumin (^99mtc-maa) has been evaluated as a useful perfusion study agent. in this study, the human absorbed dose of ^99mtc-maa was estimated with mird and mcnp methods based on animal biodistribution data and finally compared with icrp publication data. materials and methods: in this study, for investigating the biodistribution of ^99mtc-maa, after radiolabeling of maa with technetium-99m, it was injected to mice via the tail vein. after 1-120 min post injection, the mice were sacrificed and some of their tissues dissected and counted for calculating the percentage of the injected dose per gram (% id/g) and the absorbed dose. then, the obtained data was converted to equivalent data in human for each tissue. results: dose prediction shows that the highest absorbed dose is observed in the lungs (mird: 6.8e-2 mgy/mbq, mcnp: 6.32e-2 mgy/mbq). there is good agreement between the results obtained from mird and mcnp simulation for lungs. conclusion: according to the present results and comparison with icrp publication data, animal dissection model and simulation mcnp code can be useful tools for internally-absorbed dose estimation of pulmonary radiopharmaceuticals.