Assessment of the Safety of Chicken Egg Yolk Antibody (Igy) Consumption By Measuring the Activity of Antioxidant Enzymes (Superoxide Dismutase‚ Catalase‚Glutathione Peroxidase) and Malondialdehyde Concentration As A Lipid Peroxidation Marker in Mice

Production of antibodies in chickens (igy) has significantly attracted the attention of scientists. numerous publications have reported the use of igy in diagnosis, therapy and prophylaxis. production of antigen-specific antibodies in chicken can help treat and prevent infectious diseases. in this study, the safety of igy (anti e. coli o157:h7) on the antioxidant system of mice was assessed. to that end, three different doses of igy (0.9375, 1.875 and 3.75 g / kg) were administered through oral route to three treated groups and pbs to the control group. each group consisted of 18 mice. fourteen days after administration, blood samples were collected from the mice. serum malondialdehyde (mda) level and catalase, glutathione peroxidase and superoxide dismutase activity were measured using commercial kits. oral administration of igy against e.coli o157:h7 in doses of 0.9375, 1.875 and 3.75 g / kg caused no deaths and showed no toxic effects on mice. in this study, after 14 days of igy administration, there were no significant changes in the activity of antioxidant enzymes (catalase, glutathione peroxidase and superoxide dismutase) and mda serum level compared to the control group. this study’s findings revealed that oral administration of igy against e. coli o157:h7 does not show any toxic effects and does not disturb the antioxidant system in mice. these findings could be indicative of safety of oral administration of igy in mice.