Effects of pomegranate seed oil on metabolic state of patients with type 2 diabetes mellitus

Background: rapid increasing prevalence of diabetes mellitus is a serious health concern in the world. new data determined that the pathogenesis of diabetes mellitus is chronic low‑grade inflammation,resulting insulin resistance. pomegranate seed oil (pso) has anti‑inflammatory effects; though it may reduce insulin resistance and improve glycemia in diabetes mellitus. the present study has been designed to investigate the effects of pso as a natural dietary component on metabolic state of patients with type 2 diabetes mellitus. methods: in a randomized double‑blind clinical trial study,80 patients (28 men) with type 2 diabetes were randomly allocated to the intervention and control groups. the intervention group consumed pso capsules,containing 1000 mg pso twice daily (2000 mg pso),whereas controls take placebo for 8 weeks. the participants followed their previous dietary patterns and medication use. dietary factors and metabolic factors including lipid profile,fasting plasma sugar,and insulin and were assayed at the baseline and after 8 weeks. results: participants in two intervention and control group were similar regarding anthropometric and the dietary factors at baseline and after trial (p > 0.05). mean level of total cholesterol,triglyceride,low‑density lipoprotein‑cholesterol,and high‑density lipoprotein was not different significantly between groups after trial (p > 0.05). consumption of pso did not significantly affect the levels of parameters such as fasting blood sugar (fbs),insulin,hba1c,alanine transferase,and homeostasis model assessment‑insulin resistance. conclusions: consumption of 2000mg pso per day for 8 weeks had no effect on fbs,insulin resistance and lipid profile in diabetic patients. © 2016 international journal of preventive medicine.