Beneficial effects of coenzyme Q10 supplementation on lipid profile and intereukin‑6 and intercellular adhesion molecule‑1 reduction,preliminary results of a double‑blind trial in acute myocardial infarction

Background: the present investigation was aimed to improve the inflammatory factors and lipoproteins concentration in patients with myocardial infarction (mi) by supplementation with coenzyme q10 (coq10). methods: in a double‑blind,placebo‑controlled study,we measured serum concentrations of one soluble cell adhesion molecules (intercellular adhesion molecule‑1 [icam‑1]),serum concentration of intereukin‑6 (il‑6) and lipid profiles (high‑density lipoprotein‑cholesterol [hdl‑c],low‑density lipoprotein‑cholesterol [ldl‑c],total cholesterol and triglyceride [tg]) in coq10 supplementation group (n = 26) compared with placebo group (n = 26) in hyperlipidemic patients with mi. fifty‑two patients were randomized to receive 200 mg/day of coq10 or placebo for 12 weeks. results: there were no significant differences for serum ldl‑c,total cholesterol,and tg between two mentioned groups after the intervention. a significant enhancement in serum hdl‑c level was observed between groups after the intervention (55.46 ± 6.87 and 44.07 ± 6.99 mg/dl in coq10 and placebo groups,respectively p< 0.001). concentrations of icam‑1 (415.03 ± 96.89 and 453.38 ± 0.7 ng/dl coq10 and placebo groups,respectively,p = 0.001) and il‑6 (11 ± 9.57 and 12.55 ± 8.76 pg/ml coq10 and placebo groups,respectively p = 0.001) in serum were significantly decreased in coq10 group. conclusions: supplementation with coq10 in hyperlipidemic patients with mi that have statin therapy has beneficial effects on their aspects of health. © 2015 mohseni m.