The effect of purslane seeds on biomarkers of oxidative stress in diabetic patients: A randomized controlled cross-over clinical trial

Background: this study was designed to examine the effects of purslane seeds on biomarkers of oxidative stress in type 2 diabetic patients. methods: this cross-over randomized controlled clinical trial was conducted on 40 patients with type 2 diabetes. participants were randomly assigned to receive either 10 g/day purslane seeds with 240 cc low-fat yogurt (intervention group) or only 240 cc low-fat yogurt (as a control group) for 5 weeks. after a 2-week washout period,subjects were moved to the alternate arm for an additional 5 weeks. at baseline and end of each study phase,fasting blood samples were collected to quantify biomarkers of oxidative stress. results: we observed a slight decrease in plasma total antioxidant capacity in both groups,however,between-group changes were not significant (−2.67 vs. −2.95 μg/dl,p = 0.94). plasma malondialdehyde in purslane group increased slightly,however,we observed no significant effect in the control group (1.62 vs. −0.47 μg/dl,p = 0.58). although both groups had a slight reduction in plasma oxidized low-density lipoprotein (ox-ldl),we failed to find any significant effect of purslane on plasma ox-ldl (−1.06 vs. −1.71 μg/dl,p = 0.85). conclusions: this cross-over clinical trial revealed that consumption of purslane seeds for 5 weeks in type 2 diabetic patients did not result in improved oxidative stress. © 2015 zakizadeh e.