Olanzapine Versus Haloperidol: Which Can Control Stuttering Better?

Background: the aim of this study was to compare the effects of olanzapine versus haloperidol to control the signs and symptoms of stuttering. methods: ninety‑three patients were recruited in a 12‑week single‑blind randomized clinical trial, which was held between october 2009 and october 2010. forty‑three patients received olanzapine (5 mg/day) and 50 patients, haloperidol (2.5 mg/day). before and after the study, they were evaluated by a speech pathologist by van riper`s questionnaire. the data were analyzed using the spss version 16. t‑test was used to compare the data between the two groups. results: mean of stuttering score (sd) before treatment was 4.67 (0.81) and 4.40 (1.14) in haloperidol and olanzapine groups, respectively (p > 0.05). after treatment, the mean (sd) score was 2.87 (1.32) and 1.56 (0.71) in haloperidol and olanzapine groups, respectively (p = 0.000). conclusions: it seems that olanzapine does have better impact in controlling stuttering, and it may be recommended to prescribe olanzapine for stutters as the first choice to control the stuttering under a careful follow‑up.